【摘 要】
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Objective: To systematically evaluate the efficacy and safety of Qidongyixin Oral Liquid (芪冬颐心口服液) in the treatment of coronary heart disease. Methods: Randomized controlled trials (RCTs) on the treatment of coronary heart disease (CHD) with Qidongyixin O
【机 构】
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Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 1
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Objective: To systematically evaluate the efficacy and safety of Qidongyixin Oral Liquid (芪冬颐心口服液) in the treatment of coronary heart disease. Methods: Randomized controlled trials (RCTs) on the treatment of coronary heart disease (CHD) with Qidongyixin Oral Liquid (芪冬颐心口服液) were screened out by systematically searching in CNKI, Wanfang Data, VIP, Sinomed, Cochrane Library, PubMed, Embase, Web of Science, Clinical-Trials.gov. Meta-analysis of the final included studies was performed according to RevMan 5.3 software. Results: A total of 9 studies were included, with a total sample size of 1224 cases, including 612 in the experimental group and 612 in the control group. Meta-analysis results showed that: Conventional treatment, combined with Qidongyixin Oral Liquid (芪冬颐心口服液) on the treatment of CHD had a significant efficiency, which was better than conventional treatment only (RR=1.18, 95％CI [1.07-1.29], P=0.0005), and could better improve patients\' electrocardiogram (RR=1.21, 95％CI [1.08, 1.35], P=0.001), increase left ventricle ejection fraction (MD=3.84, 95％CI [3.34, 4.33], P<0.00001), and reduce left ventricular end-diastolic diameter (MD=-2.81, 95％CI [-3.84, -2.41], P<0.00001) and left ventricular end-systolic diameter (MD=-2.43, 95％CI [-3.42, -1.43], P<0.00001). Conclusion: Qidongyixin Oral Liquid (芪冬颐心口服液) can improve the effective rate of the treatment of coronary heart disease, better improve patients\' electrocardiogram, reduce the left ventricular end-diastolic and end-systolic diameter, and reduce the onset time of angina pectoris. However, the quality of the cases included in the study is relatively small, and the level of evidence is low. Therefore, RCT with large samples and rigorous design is still needed to prove the reliability of the results.
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