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目的:观察复方降糖玉液联合盐酸二甲双胍和格列美脲治疗2型糖尿病(气阴两虚证)的临床疗效和安全性。方法:80例2型糖尿病(气阴两虚证)患者随机分为观察组和对照组各40例,两组患者均给予盐酸二甲双胍片0.25~0.5 g,po,tid和格列美脲片1~2 mg,po,qd治疗,观察组在此基础上加服复方降糖玉液10 ml,po,tid。治疗12周后观察两组患者空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)及中医证候积分变化,评价临床疗效。结果:治疗后两组FPG、2 h PG及HbA1c较治疗前明显下降,且观察组下降明显优于对照组(P<0.05或0.01);观察组中医证候积分下降明显优于对照组(P<0.01);观察组临床显效率为47.5%,高于对照组(P<0.05)。结论:复方降糖玉液能有效降低2型糖尿病(气阴两虚证)患者的血糖,显著改善临床症状,安全性好,值得临床推广应用。
Objective: To observe the clinical efficacy and safety of compound Jiangtang Yuye combined with metformin hydrochloride and glimepiride in the treatment of type 2 diabetes (Qi-Yin Deficiency Syndrome). Methods: Eighty patients with type 2 diabetes (Qi-Yin Deficiency Syndrome) were randomly divided into observation group (40 cases) and control group (40 cases). Metformin hydrochloride tablets (0.25-0.5 g, po, tid and glimepiride tablets 1 ~ 2 mg, po, qd treatment, the observation group on the basis of adding compound hypoglycemic Yu liquid 10 ml, po, tid. After 12 weeks of treatment, fasting blood glucose (FPG), postprandial 2h blood glucose (2hPG), HbA1c and TCM syndrome scores were observed to evaluate the clinical efficacy. Results: The levels of FPG, 2 h PG and HbA1c in two groups decreased significantly after treatment, and the decrease in observation group was significantly better than that in control group (P <0.05 or 0.01). The decline of TCM syndrome score in observation group was significantly better than that in control group <0.01). The clinical effective rate in the observation group was 47.5%, higher than that in the control group (P <0.05). Conclusion: Compound Hypoglycemic Yu liquid can effectively reduce the blood sugar in patients with type 2 diabetes (Qi-Yin Deficiency Syndrome), significantly improve clinical symptoms and safety, and is worthy of clinical application.