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目的探讨放腹水联合腹腔注射抗生素治疗自发性细菌性腹膜炎(SBP)的效果。方法146例患者随机分为治疗组76例和对照组70例,对照组给予头孢他定针3.0静脉点滴,加阿米卡星针0.2肌内注射,每日两次,疗程14d;治疗组在对照组的基础上加腹腔穿刺放腹水隔天一次,同时给予头孢他定加阿米卡星一次用量等放腹水结束时注入腹腔,疗程14d。结果治疗组有效率(86.8%)与对照组(65.7%)比较有显著差异(P<0.01),对照组无效率(34.3%)高于治疗组(13.2%),有显著性差异(P<0.01)。结论放腹水联合腹腔注射抗生素治疗自发性细菌性腹膜炎(SBP)的效果比单静脉用药要好。
Objective To investigate the effect of combined ascitic fluid and intraperitoneal injection of antibiotics on spontaneous bacterial peritonitis (SBP). Methods One hundred and sixty-six patients were randomly divided into treatment group (n = 76) and control group (n = 70). The control group received intravenous injection of ceftazidime 3.0 and intramuscular injection of amikacin 0.2 intraperitoneally twice daily for 14 days. On the basis of the control group plus abdominal paracentesis ascites once a day, while given ceftazidime plus amikacin once the amount of such as the end of ascites into the abdominal cavity, the course of treatment 14d. Results The effective rate (86.8%) in the treatment group was significantly different from that in the control group (65.7%) (P <0.01), while the inefficiency rate in the control group (34.3%) was higher than that in the treatment group (13.2% 0.01). Conclusion Ascites combined with intraperitoneal injection of antibiotics in patients with spontaneous bacterial peritonitis (SBP) is better than monotherapy.