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吸入有害因子，特别是难溶性粒子后，肺巨噬细胞是最先受到损害的一类免疫活性细胞。研究α粒子对巨噬细胞免疫功能的效应，在阐明吸入难溶性α粒子对机体免疫功能损伤中具有重要的意义。本文以类巨噬细胞（Ｐ３８８Ｄ１）作为巨噬细胞的模拟细胞，用２３８Ｐｕ电镀源作为α辐射源，观察了α辐射对巨噬细胞免疫吞噬功能和Ｆｃ受体表达功能的影响，及这两项免疫捐标对α辐射敏感性的差异。接受较大剂量或照射后较长时间，细胞吞噬功能明显下降。随着剂量增加，细胞吞噬功能下降的速率较之Ｆｃ受体功能下降速率更快。提示细胞吞噬功能对α辐射的敏感性比Ｆｃ受体更高。照射后早期接受较小剂量照射，细胞吞噬功能呈增强性改变。
Inhalation of harmful factors, especially insoluble particles, is the first type of immune macrophage cells that are damaged. Studying the effect of alpha particles on the immune function of macrophages is of great significance in elucidating the effects of inhaling insoluble alpha particles on immune dysfunction. In this study, macrophages (P388D1) were used as the macrophages to simulate the cells. 238Pu electroplating source was used as α radiation source to observe the effect of α radiation on macrophage immune phagocytosis and Fc receptor expression. Differences in the sensitivity of immunized donors to α radiation. After receiving a larger dose or irradiation for a long time, phagocytic function decreased significantly. With dose increasing, phagocytosis decreased more rapidly than Fc receptor function. Suggesting that phagocytosis is more sensitive to alpha radiation than Fc receptors. Early exposure to smaller doses of irradiation, the phagocytic function was enhanced.