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Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expression of heat shock protein 70.However,the signaling pathway underlying this effect remains unclear.Rats were intragastrically administered absolute alcohol,causing obvious lesion of the gastric mucosa.Following pre-moxibustion at Zusanli (ST36) for 8 days,the ulcer index decreased to different degrees.The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum.None out of transection of the spinal cord,damage to the nucleus of the solitary tract,neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion at Zusanli,and heat shock protein 70 expression was obviously decreased in the gastric mucosa.These findings suggest that pre-moxibustion at Zusanli can protect the gastric mucosa against lesioning,and that the mechanism underlying this effect involves its induction of heat shock protein 70 expression.Neural pathways participate in the regulatory effects of moxibustion on heat shock protein 70 expression in the gastric mucosa.