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目的探讨肝移植治疗原发性肝癌的临床意义。方法回顾性分析88例原发性肝癌行原位肝移植患者的临床资料。按照国际抗癌联盟(UICC)制定的肝癌pTNM分期标准,随访比较不同分期患者12个月的肿瘤复发和生存情况。结果术后12个月时,I、II、Ⅲ、Ⅳ期复发率分别为0、4．8％、40．0％和71．3％(P<0．01);I、Ⅱ、Ⅲ、IV期生存率分别为100％、95．2％、71．5％和41．7％(P<0．01)。结论I、Ⅱ期原发性肝癌适合行肝移植治疗,而Ⅳ期肝癌不是肝移植手术适应证。
Objective To investigate the clinical significance of liver transplantation in the treatment of primary liver cancer. Methods The clinical data of 88 patients with primary liver cancer who underwent orthotopic liver transplantation were retrospectively analyzed. According to the pTNM staging criteria of liver cancer developed by the International Union against Cancer (UICC), the tumor recurrence and survival at 12-month follow-up were compared. Results The recurrence rates of I, II, III and IV were 0, 4.8%, 40.0% and 71.3% respectively at 12 months after operation (P <0.01) The IV survival rates were 100%, 95.2%, 71.5% and 41.7%, respectively (P <0.01). Conclusions Primary liver cancer in stage I and II is suitable for liver transplantation, while stage IV hepatocellular carcinoma is not an indication for liver transplantation.