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Cohnheim于1877年首先提出了矛盾性栓塞(paradoxical embolism,PDE)的概念,PDE 指体循环(systemic circulation)静脉系统或右心的栓子通过卵圆孔(patent foramen ovale, PFO)等不同部位的动静
Cohnheim first proposed the concept of paradoxical embolism (PDE) in 1877. PDE refers to the movement of the venous system or the right heart embolus through different parts of the patent foramen ovale (PFO)