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目的:观察丁苯酞对癫痫患者是否有神经元保护作用。方法:选取40名癫痫(主要选取部分性发作继发全面发作、全面发作的癫痫)患者,临床正常应用常规抗癫痫药物治疗后随机分为2组,每组20名患者,1组给予丁苯酞规律口服(200mg/次,3次/d),口服1疗程10天,为治疗组,1组未给予丁苯酞治疗,为对照组,另选取20名健康人,无神经系统疾患,为健康组。对40名癫痫患者发病24小时内检测NSE(神经元特异性烯醇化酶)及CRP(C反应蛋白),治疗组给予丁苯酞规律治疗,于72小时、第7天检测NSE及CRP,对照组及健康组于72小时、第7天检测血清NSE及CRP水平。结果:比较数据,丁苯酞能降低治疗组NSE及CRP水平。结论:对癫痫患者在常规应用抗癫痫药物治疗的同时给予丁苯酞的药物治疗,可减少癫痫对患者脑功能的损害。
Objective: To observe whether butylphthalide has neuroprotective effect in patients with epilepsy. Methods: Forty patients with epilepsy (mainly selected partial seizures secondary to full-blown seizures and generalized seizures) were enrolled in this study. The patients were randomly divided into 2 groups (20 patients in each group) Phthalocyanine law oral (200mg / time, 3 times / d), oral treatment for 10 days for the treatment group, a group did not give butylphthalide treatment, the control group, another 20 healthy people, no neurological disorders, for the Health group. NSE (neuron-specific enolase) and CRP (C-reactive protein) were detected within 24 hours of the onset of epilepsy in 40 patients. The treatment group was treated with butylphthalide regularly. NSE and CRP were detected at 72 hours and 7 days. Serum NSE and CRP levels were measured at 72 hours and 7 days in the group and the healthy group. Results: Comparing the data, butylphthalide can reduce the level of NSE and CRP in the treatment group. CONCLUSIONS: Drug treatment of epilepsy patients with butylphthalide while conventional antiepileptic drug treatment can reduce the damage of brain function in patients with epilepsy.