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目的了解系统性红斑狼疮(SLE)并发社区获得性肺炎(CAP)的发病率及危险因素。方法选取2005年1月至2010年12月在南方医科大学南方医院中医风湿科住院治疗的系统性红斑狼疮患者,对其多项观察指标进行单因素分析和Logistic回归分析。结果 151例SLE患者中共有44例患者诊断为社区获得性肺炎,发病率为29.1%。单因素分析提示,年龄、病程、白细胞降低、补体降低、肝功异常、肾功异常、白蛋白降低、球蛋白升高、肺间质改变、浆膜炎和免疫抑制剂与SLE患者合并CAP相关。Logistic回归分析显示,肺间质改变、补体降低、球蛋白升高、免疫抑制剂是SLE患者并发CAP的危险因素。结论积极控制SLE疾病活动,减少危险因素的发生可能是控制SLE合并CAP的有效手段。
Objective To investigate the incidence and risk factors of systemic acquired pneumonia (CAP) in patients with systemic lupus erythematosus (SLE). Methods Patients with systemic lupus erythematosus who were hospitalized in Department of Rheumatology, Nanfang Hospital, Southern Medical University from January 2005 to December 2010 were selected and univariate and logistic regression analyzes were performed on the multiple indicators. Results A total of 44 out of 151 SLE patients were diagnosed as community-acquired pneumonia with a prevalence of 29.1%. Univariate analysis suggested that age, duration of disease, leukopenia, decreased complement, abnormal liver function, abnormal renal function, decreased albumin, elevated globulin, interstitial lung disease, serositis, and immunosuppressive agents were associated with CAP in patients with SLE . Logistic regression analysis showed that interstitial lung changes, decreased complement, elevated globulin, and immunosuppressive agents were risk factors for patients with SLE complicated by CAP. Conclusions Active control of SLE disease activity and reduction of risk factors may be an effective way to control SLE with CAP.