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目的探讨肾病综合征(Nephrotic Syndrome)病人血清磷脂(PL)变化与肾损害的关系。方法采用酶促法和终点比色法对50例肾病综合征活动期患者、30例肾病综合征缓解期患者和健康对照30例,分别进行血清磷脂(PL)、总胆固醇(TCHO)含量检测。结果肾病综合征活动期组血清磷脂、总胆固醇含量分别为(400.03±114.48)mg/dl,(11.57±4.08)mmol/L明显高于肾病综合征缓解期组(228.97±28.28)mg/dl,(5.99±0.84)mmol/L和健康对照组(212.17±22.55)mg/dl,(3.82±0.61)mmol/L。结论血清磷脂检测可及早发现肾病综合征高血脂对肾小球的损害,并有助于提示降血脂治疗的疗效。
Objective To investigate the relationship between serum phospholipid (PL) and renal damage in Nephrotic Syndrome patients. Methods 50 patients with active nephrotic syndrome, 30 patients with remission of nephrotic syndrome and 30 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay and end-point colorimetric assay were used to detect serum phospholipid (PL) and total cholesterol (TCHO). Results Serum phospholipids and total cholesterol in the nephrotic syndrome group were (400.03 ± 114.48) mg / dl and (11.57 ± 4.08) mmol / L, respectively, significantly higher than those in nephrotic syndrome remission group (228.97 ± 28.28) mg / dl (5.99 ± 0.84) mmol / L and healthy controls (212.17 ± 22.55) mg / dl, (3.82 ± 0.61) mmol / L, respectively. Conclusion Serum phospholipid detection early detection of nephrotic syndrome hyperlipidemia on the glomerular damage, and help to prompt the efficacy of lipid-lowering therapy.