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亚胺唑(Imidazole)能增加离体兔心和在位狗心的收缩力,而且不伴有收缩频率的增加。本文作者将离体家兔的左、右心房分别置于盛有台氏液及通以95%氧气-5%二氧化碳的水浴中。首先在记波器上记录12个右心房的收缩频率和收缩力,为了确定剂量-反应曲线,依次增加亚胺唑浓度,自发跳动的右心房及以120次/分频率刺激的左心房均发生收缩力的增加,而且增加量相同。在给药后5分钟达到高峰,然后逐渐降低。在0.1～6.0Hz/秒整个频率范围内,亚胺唑均显著地提高心房收缩力,而且保持原来曲线形态。为了说明亚胺唑的正性收缩
Imidazole increased the contractile force of isolated rabbit hearts and dog hearts without any increase in the frequency of contractions. The authors left the rabbit left and right atrium were placed in Tyrode’s solution and through 95% oxygen -5% carbon dioxide in a water bath. First, 12 right atria were recorded on a recording device for contraction frequency and contractility. In order to determine the dose-response curve, ioxaban concentration was sequentially increased, spontaneous beating of the right atrium and left atria stimulated at a frequency of 120 beats / min Contraction increased, but the same increase. Peak 5 min after dosing and then decrease gradually. In the entire frequency range of 0.1 ~ 6.0Hz / sec, iminazole significantly increased atrial contractility, and maintain the original curve shape. To illustrate the positive contraction of iminozole