Let-7家族是最古老而保守的micro RNAs(mi RNAs)之一,由于它在许多肿瘤中表达下降或缺失,故被认为是肿瘤抑制因子。LIN28是一种高度保守的RNA结合蛋白,在多种恶性肿瘤中过度表达,通过抑制let-7而发挥致癌功能。目前认为,LIN28/let-7通路与恶性肿瘤发生发展密切相关,因此深入研究LIN28/let-7信号通路的调控机制将为恶性肿瘤的诊断和治疗提供新的策略。 The Let-7 family is one of the oldest and conserved micro RNAs (mi RNAs) and is considered a tumor suppressor because of its decreased or absent expression in many tumors. LIN28 is a highly conserved RNA-binding protein that is overexpressed in a variety of malignancies and exerts oncogenic functions by inhibiting let-7. At present, it is considered that the LIN28 / let-7 pathway is closely related to the development of malignant tumors. Therefore, in-depth study of the regulatory mechanism of LIN28 / let-7 signaling pathway will provide a new strategy for the diagnosis and treatment of malignant tumors.