为探讨脾阴虚证大鼠病理模型的造型方法，并对这种模型进行初步观察分析，每d给SD大鼠胃饲番泻叶0．8g、甲状腺片80mg，造成类脾阴虚证病理模型，观察造型前后各阶段实验动物活动状况、大便性状等有关指标。结果：该模型既出现了稀烂便、食少、腹胀、体重下降等牌虚运化失司症状，又有饮水量增加、燥动不安等阴虚内热病机的外在表现。有别于脾阳虚对照组、结果提示，番泻叶、甲状腺片合用是建立牌阴虚证病理模型的有效方法之一。 To explore the modeling method of pathological model of spleen yin deficiency rats, and preliminary observation and analysis of this model, each d to SD rat gastric feeding senna 0.8g, thyroid tablets 80mg, causing spleen yin deficiency pathology Model, observe the status of experimental animals before and after each stage of activity, stool traits and other related indicators. Results: The model showed both external symptoms such as spleen deficiency, food less, abdominal distension, weight loss and so on, and the external manifestations of Yin internal heat disease such as increased drinking water and restlessness. Different from the spleen yang deficiency control group, the results suggest that Senna, thyroid tablets combined is the establishment of card Yin deficiency syndrome one of the effective ways.