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目的探讨血清肿瘤标志物神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)联合食管黏膜脱落细胞DNA倍体在食管癌诊断中的应用价值。方法选取我院收治的经胃镜诊断为食管病变患者128例,其中64为食管癌患者,64例为食管良性病变患者,使用罗氏电化学发光免疫系统检测其血清NSE、CEA水平,采用ICM检测DNA倍体水平,分析其特异性及敏感性。结果 64例食管癌患者中有45例DNA倍体为阳性,64例食管良性病变患者中,3例DNA倍体异常,食管癌组患者的NSE、CEA水平均明显高于良性病变组,组间比较有明显差异,P<0.05,CEA、NSE以及DNA倍体对于食管癌的诊断均具有较高的特异性,而敏感性较低,3者联合检测对于食管癌的诊断有较高的敏感性以及特异性,其分别为87.50%以及84.38%。结论 NSE、CEA以及DNA倍体可以作为早期诊断食管癌的重要辅助指标,而联合检测则能够显著提高诊断的敏感性,具有一定的临床意义。
Objective To investigate the diagnostic value of DNA ploidy of serum tumor markers neuron-specific enolase (NSE), carcinoembryonic antigen (CEA) and esophageal mucosal exfoliated cells in the diagnosis of esophageal cancer. Methods 128 cases diagnosed as esophageal lesions by gastroscope in our hospital were selected. Among them, 64 were esophageal cancer patients and 64 were esophageal benign lesions. Serum NSE and CEA levels were detected by Roche electrochemiluminescence immunoassay. DNA was detected by ICM Ploidy level, analysis of its specificity and sensitivity. Results Of the 64 patients with esophageal cancer, 45 were positive for DNA ploidy. Among 64 patients with esophageal benign lesions, 3 were DNA ploidy abnormalities. The levels of NSE and CEA in esophageal cancer patients were significantly higher than those in benign lesions, P <0.05, CEA, NSE and DNA ploidy for the diagnosis of esophageal cancer has a high specificity, but less sensitive, the three combined detection of esophageal cancer diagnosis has a higher sensitivity And specificity of 87.50% and 84.38%, respectively. Conclusion NSE, CEA and DNA ploidy can be used as important auxiliary indicators for the early diagnosis of esophageal cancer, and combined detection can significantly improve the diagnostic sensitivity, with a certain clinical significance.