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目的:探讨全血细胞减少症(PCP)患者的病因,提高临床诊断准确率,为患者积极治疗提供帮助。方法:回顾性分析了2004年1月—2009年12月咸宁市第一人民医院就诊71例PCP患者的临床资料、外周血形态、骨髓细胞学检查及其他实验室检查结果,总结引起PCP常见的病因。结果:引起PCP病因较多,其中,造血系统疾病56例占78.9%,其中造血系统难治性恶性疾病33例占46.5%,包括AA占16.9%、MDS占12.7%、AL占9.9%、MM占2.8%、HL占2.8%、MF占1.4%;造血系统良性疾病23例占32.4%,包括MegA占19.9%、HPS占9.9%、IDA占2.8%;非造血系统疾病15例占21.1%,包括药物不良反应占9.9%、肝硬化占4.2%、脾功能亢进占4.2%、感染相关性疾病占2.8%。结论:对于全血减少的疾病患者,诊断时一定要紧密联系病史、体征、辅助检查等,先考虑造血系统难治性恶性疾病,再考虑造血系统良性疾病,然后考虑非造血系统疾病,做出正确诊断,力求避免误诊。
Objective: To investigate the etiopathogenisis of patients with pancytopenia (PCP), to improve the accuracy of clinical diagnosis, and to provide assistance for the active treatment of patients. Methods: The clinical data of 71 PCP patients in Xianning First People’s Hospital from January 2004 to December 2009 were retrospectively analyzed. The peripheral blood morphology, bone marrow cytology and other laboratory tests were summarized. The common causes of PCP Etiology. Results: There were many causes of PCP. Among them, 56 cases of hematopoietic system accounted for 78.9%, including 33 cases of hematopoietic system refractory malignancies accounted for 46.5%, including AA 16.9%, MDS 12.7%, AL 9.9%, MM Accounted for 2.8%, HL accounted for 2.8%, MF accounted for 1.4%; 23 cases of hematopoietic benign disease accounted for 32.4%, including MegA accounted for 19.9%, HPS accounted for 9.9%, IDA accounted for 2.8%; non hematopoietic system in 15 cases accounted for 21.1% Including adverse drug reactions accounted for 9.9%, cirrhosis accounted for 4.2%, hypersplenism accounted for 4.2%, infection-related diseases accounted for 2.8%. Conclusions: For the patients with complete blood loss, the diagnosis must be closely linked with the history, signs and auxiliary examinations, the first considering hematopoietic system refractory malignant disease, and then consider the hematopoietic system benign disease, and then consider non-hematopoietic system disease, make Correct diagnosis, to avoid misdiagnosis.