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目的:观察常规加乌司他丁治疗急性左心心力衰竭的疗效。方法:选择某医院心脏内科收治的急性左心心力衰竭110例,随机分为观察组与对照组各55例。对照组采用常规治疗,观察组在对照组基础上加用乌司他丁。比较两组血清肌钙蛋白T(cTn T)、血浆钠尿肽(BNP)水平,以及心率变异性(HRV)、Q-T离散度(QTd)、频发室性期前收缩、室性期前收缩二联律和短阵室速次数。结果:治疗后,观察组cTn T和BNP水平显著低于对照组(P<0.05);观察组HRV显著高于对照组(P<0.05),Q-T离散度、频发室性期前收缩次数、室性期前收缩二联律和短阵室速次数显著低于对照组(P<0.05)。结论:常规加乌司他丁治疗急性心力衰竭,可降低cTn T、BNP水平,增加HRV,缩小QTd,降低室性心率失常发生率。
Objective: To observe the curative effect of conventional ulinastatin in the treatment of acute left heart failure. Methods: A total of 110 cases of acute left heart failure admitted to the hospital of cardiology were randomly divided into observation group and control group with 55 cases each. The control group was treated with routine treatment, and the observation group was given ulinastatin on the basis of the control group. Serum levels of troponin T (cTn T), plasma natriuretic peptide (BNP) and heart rate variability (HRV), QT dispersion, premature ventricular systolic and ventricular premature ventricular contractions Second law and the number of occasional ventricular tachycardia. Results: After treatment, the levels of cTn T and BNP in the observation group were significantly lower than those in the control group (P <0.05); HRV in the observation group was significantly higher than that in the control group (P <0.05); QT dispersion, frequency of frequent pre- Premature ventricular contractions and ventricular tachyarrhythmia significantly lower than the control group (P <0.05). CONCLUSION: Conventional plus ulinastatin can reduce the levels of cTn T and BNP, increase HRV, reduce QTd, and reduce the incidence of ventricular arrhythmia in patients with acute heart failure.