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环磷酰胺(CTX)冲击疗法对于预防狼疮性肾炎(LN)所至的肾功能衰竭比单纯服用强的松有效已被公认。本研究旨在探讨甲基强的松龙冲击疗法在预防LN所至的肾功能衰竭方面是否和CTX冲击有同样的效果,同时探讨长程CTX和短CTX冲击对LN恶化的预防作用。病例和方法:65例患者,女60例,男5例,平均年龄29岁。全部病例符合系统性红斑狼疮的诊断标准。LN经肾活证实。65例中,血肌酐大于正常者64%,尿蛋白≥3.5克/天者62%。组织学类型大多数为弥漫增殖型。病例随机分为甲基强的松龙冲击组(25人)。给甲基强松龙1.0克/m~2静脉滴注,连续3天,然后每月1次,共6次。短程CTX冲击组(20
Cyclophosphamide (CTX) shock therapy has been recognized as effective in preventing renal failure associated with lupus nephritis (LN) over simply taking prednisone. The purpose of this study was to investigate whether methylprednisolone impact therapy has the same effect as CTX shock in preventing LN-induced renal failure and to investigate the preventive effect of long-term CTX and short CTX on LN. Cases and methods: 65 patients, 60 females, 5 males, mean age 29 years old. All cases meet the diagnostic criteria of systemic lupus erythematosus. LN via renal live confirmed. In 65 cases, serum creatinine was 64% greater than normal and urinary protein ≥ 3.5 g / day was 62%. The majority of histological types are diffuse proliferative. The patients were randomly divided into methylprednisolone impact group (25). To methylprednisolone 1.0 g / m ~ 2 intravenous infusion for 3 days, then once a month for a total of 6 times. Short-range CTX impact group (20