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在安定的药物鉴别性刺激抗焦虑模型上,中枢肾上腺素突触前α_2受体激动剂可乐定(10～60μg/kg),不仅可使安定的量效曲线显著左移,而且可使氯氮(艹卓)和Ⅰ型苯二氮(艹卓)受体激动剂CL218872对安定鉴别性刺激泛化的量效曲线显著左移。中枢肾上腺素突触前α_2受体拮抗剂育亨宾可阻断可乐定的这一作用,且使安定量效曲线显著右移。安定鉴别性刺激,可被中枢苯二氮(艹卓)受体拮抗剂Ro15-1788完全阻断,而GABA_A型受体拮抗剂荷包牡丹碱则不能阻断。结果提示,中枢去甲肾上腺素系统参与介导苯二氮(艹卓)抗焦虑作用。
In the stable anti-anxiety drug identification model, the central adrenergic presynaptic α 2 receptor agonist clonidine (10 ~ 60μg / kg), not only can make diazepam dose-effect curve significantly shifted to the left, but also to make nitrogen and nitrogen (艹 Zhuo) and Ⅰ type benzodiazepine (艹 Zhuo) receptor agonist CL218872 diazepam differential stimuli generalized dose-response curve significantly shifted to the left. Yohimbe, a presynaptic α 2 receptor antagonist of the central adrenaline, blocked this effect of clonidine and shifted the diastolic dose-response curve to the right. A stable discriminatory stimuli can be completely blocked by the central benzodiazepine receptor antagonist Ro15-1788, while the GABA A receptor antagonist bicuculline can not be blocked. The results suggest that the central norepinephrine system is involved in the mediation of benzodiazepines (Anzhuo) anti-anxiety effect.