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目的:观察卡马西平治疗苯二氮草类药物戒断综合征的疗效。方法:用卡马西平和淀粉胶囊进行为期4周的双盲空白对照观察。治疗前后用汉密顿焦虑量表(HAMA)进行评定。结果:1周后治疗组总有效率(59%)明显高于空白组(28%),但4周后两组相似,分别为88%和78%。结论:卡马西平对快速停用苯二氮艹卓类药物所出现的戒断综合征有治疗作用,随症状的减轻,卡马西平应逐渐减量。
Objective: To observe the curative effect of carbamazepine treatment of benzodiazepine withdrawal syndrome. METHODS: A double-blind, blank control study of carbamazepine and starch capsules for 4 weeks was performed. Before and after treatment with the Hamilton Anxiety Scale (HAMA) for evaluation. Results: After 1 week, the total effective rate (59%) in the treatment group was significantly higher than that in the blank group (28%), but after 4 weeks, the two groups were similar, with 88% and 78% respectively. CONCLUSION: Carbamazepine has a therapeutic effect on withdrawal symptoms of benzodiazepines that are rapidly discontinued. With the reduction of symptoms, carbamazepine should be gradually reduced.