唐氏综合征(Down Syndrome,DS)是一种先天性染色体异常,是由于在减数分裂的后期,21号染色体未分离所致,即21染色体三体综合征/先天愚型。根据相关研究表明,35岁以上的孕产妇,其生育的子女为唐氏综合征患儿的机率明显增高,约占所有DS患儿的20%[1]。DS的主要危害是患儿先天性智力障碍、特殊面容、精神体格发育迟滞,并伴有严重的 Down Syndrome (DS) is a congenital chromosomal abnormality due to the non-segregation of chromosome 21 at the end of meiosis, known as trisomy 21 / Down’s syndrome. According to relevant research shows that pregnant women over the age of 35, their childbearing children with Down syndrome significantly increased the probability of children, accounting for about 20% of all DS children [1]. The main hazards of DS children with congenital mental retardation, special face, mental retardation, and accompanied by severe