糖尿病肾病是糖尿病最主要的微血管并发症之一。此病涉及肾脏小血管和肾小球病变,造成蛋白尿排泄和滤过异常。糖尿病肾病的自然过程是从正常蛋白尿、微量蛋白尿,发展成临床蛋白尿,至终末期肾功能衰竭(end stage renal disease,ESRD)。高血压既是糖尿病肾病的一个主要特征,又是其主要的危险因素之一。两者可相互促进,高血压可促进糖尿病肾病的发 Diabetic nephropathy is one of the most important microvascular complications of diabetes. The disease involves renal small vessels and glomerular lesions, resulting in proteinuria excretion and abnormal filtration. The natural course of diabetic nephropathy is from normal proteinuria, microalbuminuria, development of clinical proteinuria, to end stage renal failure (ESRD). Hypertension is not only a major feature of diabetic nephropathy, but also one of the major risk factors. Both can promote each other, high blood pressure can promote the development of diabetic nephropathy