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为探讨内皮源性舒血管因子（ｅｎｄｏｔｈｅｌｉｕｍ－ｄｅｒｉｖｅｄｒｅｌａｘｉｎｇｆａｃｔｏｒ，ＥＤＲＦ）在急性肾功能衰竭（ＡＲＦ）发生发展中的作用及其机制，在甘油致大鼠ＡＲＦ模型上，分别观察了ＮＯ前体Ｌ－ａｒｇｉｎｉｎｅ（Ｌ－Ａｒｇ）和ＮＯ合成酶抑制剂Ｎ－ｎｉｔｒｏ－Ｌ－ａｒｇｉｎｉｎｅ（Ｌ－ＮＮＡ）的作用。实验结果表明：ＡＲＦ大鼠ＮＯ合成减少，Ｌ－Ａｒｇ能明显降低ＡＲＦ大鼠血清中的ＢＵＮ和Ｓｃｒ，尿中ＮＡＧ和肾皮质中的钙含量，而提高血清ＮＯ水平，增加肾组织ｃＧＭＰ含量，改善肾功能；Ｌ－ＮＮＡ则使ＡＲＦ恶化。提示：ＥＤＲＦ在甘油所致ＡＲＦ大鼠的发生发展中可能起重要的保护作用。
To investigate the role of endothelium-derived protective factor (EDRF) in the development and progression of acute renal failure (ARF) in rats with glycerol-induced ARF model, the effects of NO precursor L-arginine (L-Arg) and NO synthase inhibitor N-nitro-L-arginine (L-NNA). The results showed that: NO synthesis decreased in ARF rats, L-Arg can significantly reduce serum BUN and Scr in ARF rats, urine NAG and renal cortex calcium content, and increase serum NO levels and increase cGMP content in renal tissue, Improve renal function; L-NNA make ARF worse. Tip: EDRF may play an important protective role in the development of ARF rats induced by glycerol.