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目的评价黄杨宁缓释片的缓释效果。方法以乙基纤维素(EC)作为缓释材料与黄杨宁原料药混合做固体分散物,再加入其他辅料制备黄杨宁缓释片。转篮法测定释放度,酸性染料染色分光光度法测定黄杨宁的含量。结果黄杨宁缓释片1h累计释放约为总量的30%,可以达到有效治疗剂量,6h累计释放约为总量的60%,12h时基本释放完全。结论黄杨宁缓释片有较好的缓释作用,释药以扩散为主。
Objective To evaluate the sustained-release effect of Huangyangning sustained-release tablets. Methods Ethyl cellulose (EC) was used as sustained-release material mixed with flavonoids as a solid dispersion, and then other excipients were added to prepare huangyanging sustained-release tablets. The degree of release was measured by the basket method, and the content of huangyangning was determined by acid dyeing spectrophotometry. Results The cumulative release of Huangyanging Sustained-release Tablets was about 30% of the total amount for 1 hour, and the effective therapeutic dose could be achieved. The cumulative release at 6 hours was about 60% of the total, and the release was basically complete at 12 hours. Conclusion Huangyaning sustained-release tablets have better sustained-release effect, and drug release is mainly diffusion.