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目的 :了解广州地区献血人群中的输血传播病毒 (TTV)感染状况 ,探讨TTV与丙氨酸氨基转移酶(ALT)、HBsAg及抗HCV指标的相关性。方法 :用聚合酶链反应 (PCR)方法对不同献血人群血清标本进行TTV DNA检测 ,并对所有标本进行了ALT、HBsAg、抗 HCV、抗 HIV、梅毒及抗 HAV、抗 HEV、抗 HGV筛查。结果 :献血者中的TTV DNA阳性率为 7 6 % (43/ 5 6 4 ) ,其中有偿献血者和无偿献血者中的TTV DNA阳性率分别为 9 4 %、 5 9% ;单一ALT异常无偿献血者的TTV DNA阳性率明显高于ALT正常无偿献血者 (10 6 %、 4 2 % ,P <0 0 5 ) ,HBsAg及抗 HCV阳性献血者中的TTV DNA阳性率分别为 11 1%、 8 3%。结论 :本文结果显示广州地区献血者中存在TTV感染 ,而且在有偿献血者中感染率相对较高。TTV可以单独感染也可与HBV、HCV重叠感染并与ALT密切相关。
Objective: To understand the status of blood transfusion transmitted virus (TTV) infection in blood donors in Guangzhou and to explore the correlation between TTV and alanine aminotransferase (ALT), HBsAg and anti-HCV. Methods: TTV DNA was detected by polymerase chain reaction (PCR) in serum samples of different blood donors. ALT, HBsAg, anti-HCV, anti-HIV, syphilis and anti-HAV, anti-HEV and anti-HGV screening . Results: The positive rate of TTV DNA in blood donors was 76% (43/546). The positive rates of TTV DNA in blood donors and non-blood donors were respectively 9 4% and 59% The positive rate of TTV DNA in blood donors was significantly higher than that in normal ALT donors (106%, 42%, P <0 05). The positive rates of TTV DNA in HBsAg and anti-HCV positive donors were 11 1% 8 3%. Conclusion: Our results show that there is TTV infection among blood donors in Guangzhou area, and the infection rate in paid blood donors is relatively high. TTV can be infected alone, but also with HBV, HCV overlapping infection and is closely related with ALT.