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目的探讨西麻滴鼻剂对过敏性鼻炎的防治作用。方法采用2,4-二异氰酸甲苯酯为致敏原,对豚鼠行鼻内给药,建立过敏性鼻炎的实验模型,观察西麻滴鼻剂对豚鼠过敏性鼻炎模型鼻部症状的影响;以二甲苯致小鼠耳肿胀法、醋酸致小鼠腹腔毛细血管通透法观察其收缩毛细血管及抗炎的作用。结果西麻滴鼻剂能明显减轻豚鼠鼻部症状,显著抑制二甲苯所致小鼠耳廓肿胀,抑制小鼠腹腔毛细血管炎性渗出。结论西麻滴鼻剂能有效防治过敏性鼻炎。
Objective To investigate the prevention and treatment effect of Xima nasal drops on allergic rhinitis. Methods The experimental model of allergic rhinitis was established by intranasal administration of 2,4-diisocyanatotoluene as the allergen, and the effect of Xima nasal drops on nasal symptoms in guinea pigs with allergic rhinitis was observed The contractile capillaries and anti-inflammatory effects were observed by xylene-induced mouse ear swelling and acetic acid induced peritoneal capillary permeability in mice. Results Xima nasal drops can significantly reduce the nasal symptoms in guinea pigs, significantly inhibited xylene-induced mouse ear swelling, inhibit mouse peritoneal capillary inflammatory exudation. Conclusion Xima nasal drops can effectively prevent and treat allergic rhinitis.