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感染性心内膜炎(IE)的病原体中,肠球菌属的比例占10%。尽管达托霉素在体外对肠球菌属具有杀菌作用,但该药用于治疗IE的经验很少。本文分析达托霉素治疗肠球菌性心内膜炎(EIE)的有效性。从2007年1月—2011年12月,采用回顾性研究,比较达托霉素与氨苄西林-头孢曲松和常规抗生素方案(氨苄西林或万古霉素联合庆大霉素)治疗EIE的疗效。6例用达托霉素单药治疗,21例用氨苄西林/头孢曲松治疗,5例用氨苄
Infective endocarditis (IE) pathogens, Enterococcus accounted for 10%. Although daptomycin has a bactericidal effect on Enterococcus in vitro, there is little experience with the drug in the treatment of IE. This article analyzes the effectiveness of daptomycin in the treatment of enterococcal endocarditis (EIE). From January 2007 to December 2011, a retrospective study was conducted to compare the efficacy of daptomycin with ampicillin-ceftriaxone and conventional antibiotic regimens (ampicillin or vancomycin plus gentamicin) in the treatment of EIE. 6 with daptomycin monotherapy, 21 with ampicillin / ceftriaxone treatment, 5 with ampicillin