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目的观察温阳益气活血方对慢性心功能不全炎症因子的影响。方法选择符合诊断标准的慢性心功能不全患者60例,随机平均分成两组,即对照组和中西医结合治疗组。对照组给予常规西药治疗,中西医结合治疗组在常规西药治疗的基础上给予中药温阳益气活血方治疗,疗程均为15天,观察两组治疗前后彩色多普勒超声心功能和炎症因子hsCRP、TNF-α和IL-18的变化。结果两组治疗后彩色多普勒超声心功能均有改善,炎症因子hs-CRP、TNF-α和IL-18含量均降低,差异均具有统计学意义(P<0.05)。中西医结合治疗组彩色多普勒超声心功能较对照组明显改善,炎症因子hs-CRP、TNF-α和IL-18含量较对照组降低,二者差异具有统计学意义(P<0.05)。结论温阳益气活血方对慢性心功能不全具有改善心功能,降低炎症因子hs-CRP、TNF-α和IL-18含量的作用。对炎症因子hs-CRP、TNF-α和IL-18的影响可能是该药治疗慢性心功能不全的作用机制之一。
Objective To observe the effect of Warming Yang and Invigorating Qi and Activating Blood Recipe on inflammatory factors in chronic heart failure. Methods Sixty patients with chronic heart failure who meet the diagnostic criteria were randomly divided into two groups randomly: control group and Integrative Medicine group. The control group was treated with conventional western medicine. The combination of traditional Chinese and Western medicine treatment group was given Wenyang Yiqi Huoxue Decoction on the basis of routine western medicine for 15 days. The changes of color Doppler echocardiography and hsCRP, TNF-α and IL-18 changes. Results After treatment, the color Doppler echocardiography was improved in both groups. The levels of hs-CRP, TNF-α and IL-18 in the two groups were all decreased. The differences were statistically significant (P <0.05). The color Doppler echocardiography was significantly improved in Integrative Medicine group as compared with the control group. The levels of hs-CRP, TNF-α and IL-18 in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Wenyang Yiqi Huoxue Recipe can improve cardiac function and reduce the content of inflammatory factors hs-CRP, TNF-α and IL-18 in patients with chronic heart failure. The effects of hs-CRP, TNF-α and IL-18 on inflammatory cytokines may be one of the mechanisms of action of this drug in the treatment of chronic heart failure.