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目的 :探讨新生儿窒息后血浆心肌肌钙蛋白 T(Tn T)和 CK-MB变化 ,以及高压氧疗对其影响。方法 :采用电发光免疫分析法和全自动生化分析仪检测全部新生儿生后 2 4h内和 18例重复窒息新生儿、10例无窒息新生儿生后 10天的血浆 Tn T、CK-MB水平。结果 :生后 <2 4h窒息组 Tn T、CK-MB显著升高 (P<0 .0 1)。且和窒息程度有关 (P<0 .0 5 )。生后 10天 ,未予高压氧疗重度窒息组 Tn T、CK-MB明显高于无窒息组和高压氧疗组 (P<0 .0 1)。高压氧疗组和无窒息组无显著性差异 (P>0 .0 5 )。结论 :血浆CK-MB和 Tn T为早期诊断新生儿窒息后心肌损害的敏感特异性指标。高压氧疗对窒息后心肌损害有一定疗效。
Objective: To investigate the changes of cardiac troponin T (Tn T) and CK-MB in neonates with asphyxia and the effects of hyperbaric oxygen therapy on them. Methods: Plasma Tn T and CK-MB levels in all neonates within 24 hours after birth and in 18 neonates with asphyxia were detected by electrophorous immunoassay and automatic biochemical analyzer. . Results: The levels of Tn T and CK-MB in asphyxiated group <24 h after birth were significantly increased (P <0.01). And the degree of asphyxia (P <0. 05). Ten days after birth, Tn T and CK-MB in severe asphyxia group without hyperbaric oxygen therapy were significantly higher than those in non-asphyxia group and hyperbaric oxygen therapy group (P <0.01). There was no significant difference between hyperbaric oxygenation group and without asphyxia group (P> 0.05). Conclusion: Plasma CK-MB and Tn T are sensitive and specific indicators for the early diagnosis of myocardial damage after neonatal asphyxia. Hyperbaric oxygen therapy has some effect on myocardial damage after asphyxia.