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[目的]观察小柴胡汤对大鼠血及胃组织胃动素(MOT)、促胃液素(Gas)和血管活性肠肽(VIP)的影响,探讨该方促胃肠动力作用的可能机制。[方法]健康SD大鼠30只随机分为小柴胡汤、莫沙比利和0.85%氯化钠3组,每组10只。用药后采用放射免疫方法检测大鼠血和胃组织中的MOT、Gas及VIP水平。[结果]小柴胡汤组可升高血和胃组织中MOT,与0.85%氯化钠组比较差异有统计学意义(P<0.05),与莫沙比利组比较差异无统计学意义(P>0.05);小柴胡汤对血和胃组织中的Gas和VIP与0.85%氯化钠组比较P>0.05。[结论]小柴胡汤的促胃肠动力作用可能与MOT密切相关。
[Objective] To observe the effects of Xiao Chaihu Decoction on motilin (MOT), gastrin (Gas) and vasoactive intestinal peptide (VIP) in blood and stomach tissue of rats, and to explore the possible mechanism of this side in promoting gastrointestinal motility. [Methods] Thirty healthy Sprague-Dawley rats were randomly divided into three groups: Xiaochaihu Decoction, Mosapride and 0.85% sodium chloride, 10 in each group. Radioimmunoassay was used to detect MOT, Gas, and VIP levels in rat blood and stomach tissues. [Results] The Xiaochaihu decoction group could increase the MOT in the blood and stomach tissues, which was significantly different from the 0.85% sodium chloride group (P<0.05). There was no significant difference between the Xiaochaihu Decoction group and the mosapride group (P<0.05). > 0.05); Xiaochaihu Decoction compared blood and gastric tissue in Gas and VIP with 0.85% sodium chloride group P> 0.05. [Conclusion] The role of Xiaochaihu Decoction in promoting gastrointestinal motility may be closely related to MOT.