姐妹染色单体交换(sister chromatid exchange,SCE)是国外近几年建立起来的一种新技术,用于检测物理、化学、病毒等致癌、致畸、致突变(三致)物质的细胞遗传学效应。目前认为,SCE能反映DNA的损伤,可用来作为“三致”形成的指标;同时,对研究“三致”物质的活性和代谢、DNA修复、染色体断裂、细胞周期动力学、遗传性疾病、血液学和肿瘤学等均有重要意义。且SCE分析比染色体畸变分析敏感、简单、迅速,可 Sister chromatid exchange (SCE) is a new technique developed abroad in recent years to detect the cytogenetics of carcinogens, teratogenic and mutagenic substances effect. At present, SCE can reflect the damage of DNA and can be used as an indicator of the formation of “Sanzhi”. At the same time, it is of great significance to study the activity and metabolism of “Sanzhi” material, DNA repair, chromosome rupture, cell cycle kinetics, genetic diseases, Hematology and oncology, etc. are of great significance. And SCE analysis is more sensitive than chromosome aberration analysis, simple, rapid, can