海洋是生命之源,海洋生物物种占地球生物的80%以上,由于海洋生态环境的特殊性和生物链之间的密切相关性,导致海洋生物具有陆上生物无可媲美的化学结构奇特、新颖并具有特异的高活性、高药效的先导化合物,为新药研究与开发提供了大量的模式结构和药物前体。海洋生物活性物质主要包括生物信息物资、各类活性成分、海生毒素和生物功能材料等。研究海洋生物活性物质是海洋药物研究的主导方向。自20世纪60年代始,美国、日本、德国等发达国家开展了大规模的海洋生物活性成分及其功效的研究。随着科学技术的快速发展,至90年代,海洋生物已成为一门成熟的学科,为海洋药物研究奠定了良好的基础。近年来,国际上出现大 Oceans are the source of life. Marine life species account for more than 80% of the earth’s life. Due to the special nature of the marine ecological environment and the close correlation between the biological chains, marine organisms have terrific chemical structures that are unsurpassed on land. It also has specific high-activity, high-efficiency lead compounds, providing a large number of model structures and prodrugs for the research and development of new drugs. Marine biologically active substances mainly include biological information materials, various active ingredients, marine toxins and biological functional materials. Studying marine bioactive substances is the main direction of marine drug research. Since the 1960s, developed countries such as the United States, Japan, and Germany have conducted large-scale research on marine biological active ingredients and their efficacy. With the rapid development of science and technology, by the 1990s, marine biology has become a mature discipline, laying a good foundation for marine drug research. In recent years, there have been large international