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乌头Aconitum palmatum Don. 恨在印度作为一种民间草药已经使用许多年了。据报道,早自1965年印度人就从该植物中分离出5个二萜生物碱:vakognavine, palmasine,vakatisine, vakatisinine和vakatidine。作者多年来一直从事乌头二萜生物碱成分的研究,曾从印度乌头中分离出8种二萜生物碱。本文报道了2个新的二萜生物碱vakhmatine(1)和vaknmadine(2)以及2个已知生物碱阿替新atisine和hetisine。这2个新的生物碱均在C_(19)与C_(20)之间有一种胺桥,并且由C_8、C_9、C_(11)、C_(12)、C_(13)和C_(14)形成船式构型,C_(11)和C_(13)上的羟基均为α-型,这些与早期报道的结构有所不同。乌头乙醇提取物经常规pH梯度萃取分
Aconitum palmatum Don. Aconitum has been used in India as a folk herb for many years. According to reports, as early as 1965, Indians isolated five diterpene alkaloids from the plant: vakomagnavine, palmasine, vakatisine, vakatisinine and vakatidine. The author has been engaged in the study of alkaloids in Aconitum diterpenoids for many years and isolated eight diterpene alkaloids from Aconitum indicum. This article reports two new diterpene alkaloids vakhmatine(1) and vaknmadine(2) as well as two known alkaloids aldosine and hetisine. The two new alkaloids all have an amine bridge between C 19 and C 20 , and are composed of C_8, C_9, C_(11), C_(12), C_(13), and C_(14). Forming a boat configuration, the hydroxyl groups on C_(11) and C_(13) are all α-type, which are different from those reported earlier. Aconitum ethanol extracts were extracted by conventional pH gradient extraction