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最近,Okuyama报道,Bestatin会引起癌细胞的分化。因此,有必要弄清楚引起分化作用是否由于Bestatin的治疗效应。作者同时试验了抑制氨肽酶B的ArphameninesA和B:抑制氨肽酶A的Amastatin;抑制碱性磷酸酶的Forphenicinol和Forphenicine等这些免疫改变因素在抑制生长和诱导人体前髓细胞性白血病细胞HL-60分化中的作用。HL-60细胞是培养在RPMI1640培养基中,其中添加15%的小牛血清(Grand Isl-and Biochemical Co.Grand Island,N.
Recently, Okuyama reports that Bestatin causes cancer cells to differentiate. Therefore, it is necessary to find out if the differentiation effect is due to the therapeutic effect of Bestatin. The authors also tested the inhibition of aminopeptidase Arphamenines A and B: inhibition of aminopeptidase A Amastatin; inhibition of alkaline phosphatase Forphenicinol and Forphenicine and other immune alterations in the inhibition of growth and induction of human promyelocytic leukemia cells HL- 60 differentiation in the role. HL-60 cells were cultured in RPMI 1640 medium supplemented with 15% fetal bovine serum (Grand Isl-and Biochemical Co. Grand Island,