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目的 探讨甲状腺功能亢进、低下及正常时对大鼠血清IL -8含量的影响。方法 应用他巴唑和优甲乐分别灌胃 ,人为造成大白鼠甲状腺功能低下和甲状腺功能亢进状态[1] ,分别检测用药 10d、停药 10d和正常对照组大鼠血清IL -8、T3 、T4和TSH浓度。结果 用药 10d时他巴唑组、优甲乐组大鼠血清IL -8浓度明显高于正常对照组 (P <0 0 5 ) ,而他巴唑组和优甲乐组比较血清IL -8浓度无差别 (P >0 0 5 ) ;停药 10d时他巴唑组、优甲乐组大鼠血清IL -8浓度明显降低 (与用药 10d时比较P <0 0 5 ) ,与正常对照组比较已无差别 (P >0 0 5 )。结论 大鼠血清IL -8浓度在甲状腺功能低下和亢进时升高 ,据此推测IL -8可能与AITD发病有关 ,且血清IL -8水平的动态变化可作为判断AITD的转归、确定停药时机的一个有用指标。
Objective To investigate the effects of hyperthyroidism, low and normal serum IL-8 levels in rats. Methods Methimazole and Euthyrox were administered intragastrically, artificially causing hypothyroidism and hyperthyroidism in rats [1]. The levels of IL-8, T3, T4 and TSH concentrations. Results The concentration of IL-8 in the methimazole group and the Euthyrox group was significantly higher than that of the normal control group (P <0.05) on the 10th day after treatment, while the levels of IL-8 in the methimazole group and the Euthyrox group (P> 0.05). The concentration of IL-8 in methimazole group and Euthyrox group was significantly decreased at 10 days after drug withdrawal (P <0 05 compared with that on the 10th day after drug administration), compared with the normal control group No difference (P> 0.05). Conclusions The concentration of IL-8 in rat serum is elevated in hypothyroidism and hyperthyroidism. It is speculated that IL-8 may be related to the pathogenesis of AITD. The dynamic change of serum IL-8 level can be used as the prognosis of AITD. A useful indicator of timing.