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目的:探讨猪肺表面活性物质联合酚妥拉明治疗足月新生儿呼吸衰竭临床疗效。方法:血气分析及X线资料完整的120例足月新生儿呼吸衰竭患儿随机双盲分成对照组和实验组,实验组在对照组病因治疗和供氧治疗的基础上加用酚妥拉明3μg/(kg.min),微量泵2 h匀速输入,每8 h 1次,视病情轻重逐渐延长间隔时间,直到停药,同时气管内滴注猪肺表面活性物质100～200 mg一次。结果:治疗前和治疗24 h后,实验组血气分析差值PO2为(59.1±18.7)mm Hg,PCO2为-(43.9±8.5)mm Hg,PO2/FiO2为(239.7±57.7)mm Hg;对照组血气分析差值PO2为(30.3±9.7)mm Hg,PCO2为-(33.8±19.7)mm Hg,PO2/FiO2为(106.3±46.9)mm Hg。治疗24 h后血气分析结果显著改善,治疗效果两组比较差异有统计学意义(P<0.01)。结论:猪肺表面活性物质联合酚妥拉明治疗足月新生儿呼吸衰竭效果好,针对病情较重的患儿应早期使用。
Objective: To investigate the clinical efficacy of porcine pulmonary surfactant in combination with phentolamine in treatment of full-term neonatal respiratory failure. Methods: 120 cases of full-term neonatal respiratory failure with blood gas analysis and complete X-ray data were randomly divided into control group and experimental group. The experimental group was given phentolamine on the basis of etiological treatment and oxygen therapy in the control group 3μg / (kg.min). The micropumps were fed at a constant rate of 2 hours and once every 8 hours. The animals were treated for prolonged interval until the drug was discontinued. At the same time, 100-200 mg of the pulmonary surfactant was instilled once. Results: Before treatment and 24 h after treatment, the difference of PO2 was (59.1 ± 18.7) mm Hg, the mean value of PCO2 was - (43.9 ± 8.5) mm Hg and the PO2 / FiO2 was (239.7 ± 57.7) mm Hg in the experimental group Group PO2 was (30.3 ± 9.7) mm Hg, PCO2 was - (33.8 ± 19.7) mm Hg, and PO2 / FiO2 was (106.3 ± 46.9) mm Hg. Blood gas analysis results were significantly improved 24 h after treatment, the treatment effect was statistically significant difference between the two groups (P <0.01). Conclusion: The combination of porcine pulmonary surfactant with phentolamine is effective in treating full-term neonatal respiratory failure and should be used early in children with severe illness.