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目的:探讨系统性红斑狼疮( SLE)患者治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和可溶性白细胞介素-2受体(sIL-2R)的水平变化及对免疫功能的影响。方法:采用固相酶标记化学发光免疫分析技术检测40例SLE患者激素治疗前后血清TNF-α、IL-6和sIL-2R水平,应用免疫速率散射比浊法测定免疫球蛋白G(IgG)和补体3(C3)水平。以30例体检正常者作对照。结果:40例SLE患者治疗前活动期血清IgG、TNF-α、IL-6和sIL-2R水平明显高于正常对照组,而C3水平明显低于正常对照组,均P<0.01。经激素治疗后(稳定期),SLE患者血清IgG、TNF-α、IL-6和sIL-2R水平显著下降,C3显著升高,均P<0.01,但IgG、C3、TNF-α和IL-6水平仍与正常对照组有显著统计学差异(P<0.01)。结论:SLE患者TNF-α、IL-6和sIL-2R表达增加,提示SLE的发病过程涉及免疫紊乱和细胞因子失平衡。
Objective: To investigate the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in patients with systemic lupus erythematosus Changes and the impact on immune function. Methods: The levels of serum TNF-α, IL-6 and sIL-2R in 40 SLE patients before and after hormone therapy were measured by enzyme-linked immunosorbent assay (CLIA). Immunoglobulin G (IgG) Complement 3 (C3) levels. 30 cases of physical examination as a control. Results: The levels of serum IgG, TNF-α, IL-6 and sIL-2R in 40 SLE patients before treatment were significantly higher than those in normal control group, while the levels of C3 were significantly lower than those in control group (all P <0.01). The levels of serum IgG, TNF-α, IL-6 and sIL-2R in SLE patients decreased significantly after C3d treatment (P <0.01) 6 levels were still significantly different from the normal control group (P <0.01). Conclusion: The expression of TNF-α, IL-6 and sIL-2R in patients with SLE increased, suggesting that the pathogenesis of SLE involves immune disorders and cytokine imbalance.