论文部分内容阅读
氟斑牙又称氟牙症或者斑釉牙,是因儿童在牙齿发育时期从食物、饮水、甚至空气中接触过多的氟所导致儿童牙釉质发育不全,是一种慢性氟中毒的早期症状[1]。随着地方性氟中毒发病机制研究的发展,对高氟水平对骨损伤的分子机制已经成为慢性氟中毒研究的重点[2]。在同样地高氟环境下,不同儿童因存在遗传易感性的差异,其耐受性也存在一定差异。近年研究发现,雌激素对骨骼发育有十分明显的影响,雌激素受体(ER)的基因多态性对雌激素活性的影响显
Fluorosis, also known as dental fluorosis or spot glaze teeth, is a result of early symptoms of chronic fluorosis due to children’s enamel hypoplasia due to excessive exposure of fluoride to food, drinking water and even air during the tooth development period [1]. With the development of the research on the pathogenesis of endemic fluorosis, the molecular mechanism of bone damage caused by high fluoride levels has become the focus of chronic fluorosis research [2]. In the same high fluoride environment, different children due to the presence of genetic susceptibility differences, its tolerance there are some differences. Recent studies have found that estrogen on skeletal development has a very significant impact, estrogen receptor (ER) gene polymorphism on the activity of estrogen significant