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袋泡剂为一种新剂型,具有溶出快、体积小、服用方便等优点。实验比较了全生药型“通便茶”袋泡剂与汤剂的质量,选择蒽醌类化合物的定性分析、大黄素的含量测定、袋泡剂的浸出速率测定、水溶性浸出物测定及对大鼠在体大肠内容物推进作用的影响等为指标。结果表明:“通便茶”袋泡剂与汤剂所含蒽醌类化合物的种类基本一致,游离大黄素袋泡剂为汤剂的2倍,结合型大黄素为3倍以上,水溶性浸出物袋泡剂为汤剂的1.9倍,对大鼠在体大肠内容物的推进作用两者无明显差异(p>0.05)。提示该处方可以用袋泡剂代替汤剂。
The foaming agent is a new formulation with the advantages of fast dissolution, small volume and easy administration. The quality of the whole drug-type “Gong-Tong” teabags and decoctions was compared. Qualitative analysis of quinone compounds, determination of emodin content, determination of leaching rate of the foaming agent, determination of water-soluble extracts, and The influence of rats on the propulsion of the body’s large intestine contents is an indicator. The results showed that the types of anthraquinone compounds contained in the “Guan-Lei Tea” and the decoction were basically the same, and the free emodin pouch was twice as much as the decoction, the combined emodin was more than 3 times, and the water-soluble leaching was The bag foam agent was 1.9 times that of the decoction, and there was no significant difference in the promoting effect of the rats’ intestine contents (p>0.05). It is suggested that the prescription can be used as a substitute for decoction.