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目的分析洋葱伯克霍尔德菌(BC)感染患者的临床特征及分离菌的体外药物敏感性,探讨该菌所致感染的治疗特点。方法回顾性分析2005年1月至2007年12月我院BC感染81例患者的感染类型、临床表现及易感因素等,分析分离菌对抗菌药的敏感性。结果81例均属医院感染,包括肺部感染62例、血流感染11例、尿路感染5例及伤口感染3例。所有患者均有神经系统疾病、恶性肿瘤等基础疾病及使用呼吸机等易感因素。对于该菌敏感率超过80%的抗菌药有头孢他啶、美罗培南、哌拉西林/他唑巴坦;较敏感的药物尚有复方磺胺甲口恶唑、环丙沙星、头孢哌酮/舒巴坦。结论BC感染都为院内感染,感染患者都有基础疾病或易感因素;该菌对抗菌药物的耐药性高,应根据药敏结果选用抗菌药。
Objective To analyze the clinical characteristics of Burkholderia cepacia (BC) infection and the drug susceptibility of isolated bacteria in vitro, and to explore the therapeutic characteristics of the infections caused by the bacteria. Methods The infection types, clinical manifestations and susceptibility factors of 81 patients with BC infection in our hospital from January 2005 to December 2007 were analyzed retrospectively. The sensitivity of the isolates to antibacterials was analyzed. Results All the 81 cases were nosocomial infection, including 62 cases of pulmonary infection, 11 cases of bloodstream infection, 5 cases of urinary tract infection and 3 cases of wound infection. All patients had neurological diseases, malignant tumors and other underlying diseases and the use of ventilator and other susceptible factors. For the antibacterial rate of more than 80% of the bacteria ceftazidime, meropenem, piperacillin / tazobactam; more sensitive drugs are compound sulfamethoxazole, ciprofloxacin, cefoperazone / Tan CONCLUSIONS: All BC infections are nosocomial infections. Infection patients have underlying diseases or predisposing factors. The bacteria are highly resistant to antimicrobial agents and antibacterials should be selected based on their antimicrobial susceptibility.