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为获取正常人胃液内表皮生长因子（ＥＧＦ）的生理浓度，探讨ＥＧＦ在胃、＋二指肠良恶性疾病中可能产生的作用，初探ＥＧＦ与幽门螺杆菌（Ｈｐ）感染间的相互关系，用放免方法测定了不同年龄组正常人、慢性胄炎、消化性溃疡、胃癌患者胃液内ＥＧＦ的含量，并对部分活动性胃炎及活动期溃疡伴Ｈｐ感染的患者给予抗Ｈｐ及抗溃疡治疗，测定其治疗前后ＥＧＦ含量变化。结果表明各年龄组间胃液内ＥＧＦ含量无显著差异，与年龄关系不大；胃癌患者胃液内ＥＧＦ含量明显增高，胃炎及溃疡病患者明显降低，提示ＥＧＦ分泌低下可能与胃良性疾病的发病有一定关系；ＥＧＦ浓度与胃肿瘤发生也有一定关系。随着Ｈｐ清除，组织学胃炎改善，溃疡的意合，ＥＧＦ含量恢复正常。提示Ｈｐ可能影响ＥＧＦ的生成与分泌。
In order to obtain the physiological concentration of epidermal growth factor (EGF) in normal human gastric juice, the possible role of EGF in gastric and duodenal benign and malignant diseases was explored. The relationship between EGF and Helicobacter pylori (Hp) infection was discussed. The radioimmunoassay method was used to determine the content of EGF in the gastric juice in patients of different age groups, chronic carbuncles, peptic ulcer and gastric cancer. Anti-Hp and anti-ulcer treatment were given to some patients with active gastritis and active ulcer accompanied by Hp infection. The EGF content before and after treatment changes. The results showed that there was no significant difference in EGF content in gastric juice among all age groups, but not with age. The content of EGF in gastric juice was significantly higher in patients with gastric cancer and the patients with gastritis and ulcer were significantly lower, suggesting that the low EGF secretion may be related to the pathogenesis of gastric benign disease Relationship; EGF concentration and gastric tumor also have a certain relationship. Hp clearance, histological improvement of gastritis, ulcer of the agreement, EGF content returned to normal. Tip Hp may affect EGF production and secretion.