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目的 探讨伊贝沙坦、苯那普利联合用药对原发性高血压 (EH)病人左室肥厚 (LVH )的逆转作用。方法 EH伴有LVH病人 112例随机分为A组 (伊贝沙坦 150mg/d ,3 8例 )、B组 (苯那普利 10mg/d ,3 7例 )和C组 (伊贝沙坦 150mg/d ,加苯那普利 10mg/d ,3 7例 )。治疗 3周时若血压≥ 160 / 95mmHg ,则伊贝沙坦和苯那普利剂量分别增加 1倍。总疗程共 6个月 ,治疗前后 2 4h动态血压监测和彩色超声多普勒检测左室相关指标 ,计算左室重量指数 (LVMI)。结果 ①三组均能显著降低LVMI(P <0 0 1) ,其中A组和B组LVMI的降低差异无显著意义 (P >0 0 5) ,C组LVMI降低较A组、B组更为显著 ,差异有显著意义 (P <0 0 1)。②三组治疗前 2 4h平均收缩压、平均舒张压差异无显著意义 (P >0 0 5) ,治疗后 2 4h平均收缩压、平均舒张压均较治疗前显著降低 (P <0 0 1) ,但治疗后三组间比较均无明显差异 (P >0 0 5)。结论 伊贝沙坦、苯那普利均能逆转EH病人LVH ,联合用药疗效更为显著 ,这种协同作用与降压效应无关
Objective To investigate the reversal effects of irbesartan and benazepril on left ventricular hypertrophy (LVH) in patients with essential hypertension (EH). Methods One hundred and two patients with LVH were randomly divided into group A (irbesartan 150 mg / d, 38 patients), group B (benazepril 10 mg / d, 37 patients) and group C 150mg / d, benazepril 10mg / d, 37 cases). At 3 weeks of treatment, if the blood pressure was ≥ 160/95 mm Hg, the dose of irbesartan and benazepril increased by a factor of 2. The total course of treatment was 6 months, 24 h before and after treatment of ambulatory blood pressure monitoring and color Doppler ultrasound-related indicators of left ventricular, left ventricular mass index (LVMI). Results ① The LVMI was significantly decreased in all three groups (P <0.01). There was no significant difference in LVMI between group A and group B (P> 0.05), and the LVMI in group C was lower than that in group A and group B Significantly, the difference was significant (P <0.01). ② The average systolic blood pressure and average diastolic blood pressure were not significantly different at 24 hours before treatment (P> 0.05), and the average systolic blood pressure and mean diastolic blood pressure at 24 hours after treatment were significantly lower than those before treatment (P <0.01) , But there was no significant difference between the three groups after treatment (P> 0.05). Conclusion Both irbesartan and benazepril can reverse the LVH in patients with EH, and the combination therapy is more effective, which has nothing to do with the hypotensive effect