目的 :探讨脑出血过程中中枢神经系统神经肽Y(NPY)含量的动态变化及意义。方法 :采用胶原酶和肝素联合注入尾状核的方法建立大鼠脑出血模型 ,测定出血前、出血后 30min ,6、1 2、2 4、48及 72h血肿周边、下丘脑及脑干NPY的活性。结果 :脑出血后血肿周边、下丘脑及脑干NPY的含量同步升高 ,并于 2 4h达峰值 ,48～ 72h开始回落 ,但仍显著高于出血前 (P <0 0 1 )。结论 :脑出血过程中 ,脑组织NPY活性增强 ,导致局部脑血流量减少 ,最终加重神经细胞损害 Objective: To investigate the dynamic changes and significance of neuropeptide Y (NPY) in central nervous system during intracerebral hemorrhage. Methods: The model of intracerebral hemorrhage was established by injecting collagenase and heparin into caudate nucleus. The levels of NPY in the perihematoma, hypothalamus and brainstem were measured before hemorrhage, 30 min, 6 1, 2, 4, 48, 48 and 72 h after hemorrhage active. Results: The contents of NPY in the perihematoma, hypothalamus and brainstem of the hematoma increased synchronously after ICH, reaching the peak at 24 h and 48 h to 72 h, but still significantly higher than that before hemorrhage (P <0.01). Conclusion: During the process of intracerebral hemorrhage, the activity of NPY in the brain is enhanced, which leads to the decrease of the local cerebral blood flow and eventually aggravates the damage of nerve cells