众所周知,真菌病的代谢物,尤其是黄曲霉毒素具有致突变和致癌作用。流行病学已证实,家禽食用黄曲霉毒素污染的饲料,可产生食管和肝脏肿瘤。对于粮食被黄曲霉毒素污染的第三世界发展中国家,人口流行病学研究亦发现,食管和肝脏肿瘤发生率很高。在患者血液和尿液中均存在黄曲霉毒素,尤其是黄曲霉毒素B_1。对150例健康志愿者和100例肺癌患者进行检测,发现健康志愿者中仅有1例在血清中含有少量黄曲霉素G_1(0.40ng/ml),而肺癌 It is well known that metabolites of fungal diseases, especially aflatoxins, have mutagenic and carcinogenic effects. Epidemiology has confirmed that poultry feed on aflatoxin-contaminated feed can produce esophageal and liver tumors. For third-world developing countries where food is contaminated with aflatoxin, demographic epidemiological studies have also found a high incidence of esophageal and hepatic tumours. Aflatoxins, especially aflatoxin B_1, are present in both the patient’s blood and urine. A total of 150 healthy volunteers and 100 lung cancer patients were tested and found that only 1 of the healthy volunteers contained a small amount of aflatoxin G 1 (0.40 ng/ml) in the serum, whereas lung cancer