论文部分内容阅读
目的:研究霉酚酸酯(MMF)治疗难治性IgA肾病的疗效及安全性。方法:根据Lee分级选择病理诊断为IgA肾病Ⅳ~Ⅴ级曾用皮质激素治疗效果不佳,蛋白尿>1·5g/24h、血肌酐<200μmol/L的患者12例,给予MMF1·5~2·0g/d,3个月后逐渐减量,疗程至少6个月,同时采用皮质激素30~60mg/d联合治疗,分别于治疗前及治疗后6个月测定尿蛋白定量,血清肌酐、血清白蛋白、血脂、血常规等多项指标。结果:治疗6个月后,尿蛋白定量、血清白蛋白、胆固醇、血清肌酐较治疗前明显下降(P<0·05,P<0·01)。结论:MMF是治疗难治性IgA肾病有效的免疫抑制剂,且不良反应少、疗效好。
Objective: To study the efficacy and safety of mycophenolate mofetil (MMF) in the treatment of refractory IgA nephropathy. Methods: According to Lee classification, pathological diagnosis of IgA nephropathy grade Ⅳ ~ Ⅴ was treated with corticosteroids ineffective, proteinuria> 1.5g / 24h, serum creatinine <200μmol / L in 12 patients, given MMF1.5 ~ 2 0g / d, 3 months after the gradual reduction of at least 6 months course of treatment, combined with corticosteroid 30 ~ 60mg / d treatment, respectively, before and 6 months after treatment urinary protein, serum creatinine, serum Albumin, blood lipids, blood and many other indicators. Results: Urinary protein, serum albumin, cholesterol and serum creatinine were significantly decreased 6 months after treatment (P <0.05, P <0.01). Conclusion: MMF is an effective immunosuppressive agent for the treatment of refractory IgA nephropathy with less adverse reactions and good curative effect.