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目的基于新辅助放化疗探讨腹腔镜与传统开放手术治疗低位直肠癌对患者并发症及远期预后的影响。方法将244例低位直肠癌患者随机分为试验组和对照组各122例。术前2组患者均给予新辅助化疗治疗,试验组选择腹腔镜手术,对照组选择开腹手术治疗,观察比较2组患者并发症发生率。结果试验组并发症发生率低于对照组,差异亦有统计学意义(P<0.05)。试验组治疗后保肛率高于对照组,复发率和病死率均低于对照组,差异均有统计学意义(P<0.05)。结论术前新辅助放化疗后采用腹腔镜治疗低位直肠癌具有更低的并发症发生率且预后较好。
Objective To investigate the effect of laparoscopic and traditional open surgery on patients with low rectal cancer and its long-term prognosis based on neoadjuvant chemoradiotherapy. Methods 244 cases of low rectal cancer patients were randomly divided into experimental group and control group of 122 cases. Neoadjuvant chemotherapy was given to the two groups before surgery. Laparoscopic surgery was performed in the experimental group and laparotomy in the control group. Complications were compared between the two groups. Results The incidence of complications in the experimental group was lower than that in the control group, and the difference was also statistically significant (P <0.05). The anal sphincter preservation rate in experimental group was higher than that in control group, and the recurrence rate and mortality were lower than those in control group (P <0.05). Conclusions The preoperative neoadjuvant chemoradiation after laparoscopic treatment of low rectal cancer has a lower incidence of complications and the prognosis is good.