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目的：探讨胃液中肿瘤标志物对诊断胃癌的临床价值。方法：通过胃镜抽取３０例胃癌和３８例胃溃疡患者的空腹胃液。用放射免疫法检测胃液中 ＣＥＡ、 ＣＡ５０、 Ｆｅｐ的含量。结果：胃癌与胃溃疡患者胃液ＣＥＡ测定值分别为 ± ｓ４９．１３±２４．９ｇ／Ｌ及１５．９±１３．８４ｇ／Ｌ（Ｐ＜０．０１），ＣＡ５０测定值分别为 ± ｓ ５６．５９±３１．３Ｋｕ／Ｌ及４０．２４±１６． ５Ｋｕ／Ｌ（Ｐ＜０．０５）， Ｆｅｐ测定值分别为 ４７． ７１± ３８５ｇ／Ｌ及 ３８．８２ ± ２９．０３ｇ／Ｌ（Ｐ＞０．０５）。胃癌组胃液 ＣＥＡ、 ＣＡ５０的灵敏度分别是 ５３．５％及 ４６．７％联合检测 ＣＥＡ与 ＣＡ５０的灵敏度为 ８０％。结论：检测胃液肿瘤标志物对鉴别诊断良恶性胃病有一定的临床价值．
Objective: To investigate the clinical value of tumor markers in gastric juice in the diagnosis of gastric cancer. Methods: Fasting gastric juice was collected from 30 patients with gastric cancer and 38 patients with gastric ulcer by gastroscope. The contents of CEA, CA50, Fep in gastric juice were detected by radioimmunoassay. Results: The CEA values of gastric juice in patients with gastric cancer and gastric ulcer were ± s49.13 ± 24.9 g / L and 15.9 ± 13.84 g / L, respectively (P <0.01). The measured values of CA50 were ± s 56. 59 ± 31.3Ku / L and 40.24 ± 16. 5Ku / L (P <0.05), Fep measured values were 47. 71 ± 385 g / L and 38.82 ± 29.03 g / L (P> 0.05). The gastric juice CEA, CA50 sensitivity of gastric cancer were 53.5% and 46.7% of the combined detection of CEA and CA50 sensitivity was 80%. Conclusion: The detection of gastric tumor markers for the differential diagnosis of benign and malignant stomach have some clinical value.