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可溶性主要组织相容性复合体I(soluble major histocom-patibility complex classⅠ,sMHCⅠ),近年来逐渐成为研究热点。该类分子同造血系统恶性肿瘤疾病相关[1],在患者的血清中,其水平显著升高。在功能上,sMHCⅠ可通过诱导凋亡的方式清除抗肿瘤细胞,具有免疫逃逸分子功能,然而其产生机制还不清楚。调控sMHCⅠ的产生,有望为造血系统恶性肿瘤疾病的
In recent years, soluble major histocompatibility complex class I (sMHCⅠ) has become a hot research topic. These molecules are associated with hematopoietic malignancies [1], and their levels are significantly elevated in patients’ sera. Functionally, sMHC I can clear anti-tumor cells by inducing apoptosis, and has the function of immune escape molecule. However, its mechanism of production is unclear. Regulation of sMHC Ⅰ production, is expected to hematopoietic malignancies disease