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我们对五倍子有效成分9201的癌化学预防作用进行了系统的研究,并从器官、组织和分子水平上深入探讨了9201的抗始发突变、抗促癌、抗化学致癌和抗氧化作用及其分子机理。应用苯并芘B(a)P诱发V_(79)细胞体外转化模型,B(a)P诱发A/J小鼠肺腺瘤模型以及DMBA/巴豆油诱发的小鼠皮肤乳头状瘤模型,证明:9201(10μg/ml、20μg/ml)能明显地抑制苯并芘(0.5μg/ml)对中国仓鼠肺细胞(V_(79))的恶性转化;在体内9201(20mg/kg,60mg/kg)明显抑制苯并芘诱发A/J小鼠肺腺瘤的形成,使生瘤率降低,每只鼠的
We systematically studied the cancer chemopreventive effects of gallnut active ingredient 9201, and deeply discussed the anti-primary mutations, anti-cancer, anti-carcinogenic, and anti-carcinogenic and anti-oxidative effects of 9201 and their molecules at the organ, tissue, and molecular level. mechanism. The in vitro transformation model of V_(79) cells induced by benzopyrene B(a)P, the lung adenoma model induced by B(a)P in A/J mice and the mouse skin papilloma model induced by DMBA/croton oil were proved. : 9201 (10 μg/ml, 20 μg/ml) significantly inhibited the malignant transformation of hamster lung cells (V_(79)) by benzopyrene (0.5 μg/ml); in vivo 9201 (20 mg/kg, 60 mg/kg) ) Significantly inhibited benzopyrene-induced lung adenoma formation in A/J mice, resulting in reduced tumor rate per mouse