目的探讨有氧运动对绝经前女性非酒精性单纯性脂肪肝患者的胰岛素抵抗的影响。方法选取2009年7-12月在我院健康体检中心诊断为非酒精性单纯性脂肪肝患者100例,均为绝经前女性患者。随机分成基础治疗组和有氧运动组,每组各50例。基础治疗组给予口服维生素C、维生素E、二甲双胍、健康知识宣传教育、改变不良生活方式、低脂饮食等基础治疗。有氧运动组在上述基础治疗同时进行有氧运动。治疗前及治疗后6个月,所有患者采取静脉血检测空腹血糖(FBG)、血清胰岛素(FINS),检查肝脏B超;计算胰岛素抵抗指数(HOMA-IR)。结果与基础治疗组比较,在干预6月后有氧运动组患者的空腹血糖、胰岛素水平和胰岛素抵抗指数明显下降(P<0.05)。结论有氧运动能有效改善绝经前女性非酒精性单纯性脂肪肝患者的空腹血糖、胰岛素水平和胰岛素抵抗。 Objective To investigate the effect of aerobic exercise on insulin resistance in premenopausal women with non-alcoholic simple fatty liver disease. Methods A total of 100 patients with non-alcoholic simple fatty liver diagnosed in our hospital from July to December 2009 were selected, all of whom were premenopausal women. Randomly divided into basic treatment group and aerobic exercise group, 50 cases in each group. The basic treatment group was given oral vitamin C, vitamin E, metformin, public health education, change the way of life, low-fat diet and other basic treatment. Aerobic exercise group in the above basic treatment of aerobic exercise. Before treatment and 6 months after treatment, all patients received fasting blood glucose (FBG), serum insulin (FINS) and liver ultrasonography (BMI); and calculate HOMA-IR. Results Compared with the basic treatment group, the fasting blood glucose, insulin level and insulin resistance index decreased significantly in the aerobic exercise group after 6 months of intervention (P <0.05). Conclusion Aerobic exercise can effectively improve fasting blood glucose, insulin and insulin resistance in nonalcoholic fatty liver disease in premenopausal women.