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纤维粘连蛋白(Fn)是体内一种重要的结构蛋白和调理素,参与许多疾病的发病过程。本研究在吴县地区,对正常人(28名)、各期矽肺病人(119名)以及接触石英尘5年以上的健康工人(40名)的血清Fn 水平进行了调查研究,结果表明,血清内Fn 平均含量正常人为194.15μg/ml,0—Ⅰ、Ⅰ、Ⅱ、Ⅲ期矽肺患者分别为244.4(?)μg/ml、249.99μg/ml、264.60μg/ml、232.52μg/ml,均明显地高于正常人。各期矽肺患者之间无差异。接尘5年以上工人血清内Fn 含量偏高(222μg/ml),但尚与正常人无差异。本研究结果提示测定血清内Fn 浓度有助于矽肺的诊断。
Fibronectin (Fn) is an important structural protein and opsonin in the body, involved in the pathogenesis of many diseases. In this study, Fn levels in normal subjects (28 subjects), silicosis patients (119 subjects) and healthy workers (40 subjects) exposed to quartz dust for more than 5 years were investigated in Wuxian region. The results showed that serum The average content of Fn was 194.15μg / ml in normal people, and 244.4μg / ml, 249.99μg / ml, 264.60μg / ml and 232.52μg / ml respectively in 0-Ⅰ, Ⅰ, Higher than normal. There was no difference between patients with silicosis. The serum Fn content of workers exposed to dust for more than 5 years was high (222μg / ml), but no difference was found between the two groups. The results of this study suggest that the determination of serum Fn concentration contributes to the diagnosis of silicosis.